Megalencephaly

• Familial

• Cerebral gigantism (Soto syndrome)

• Neurocutaneous disorders

  • Neurofibromatosis Type I, Incontinentia Pigmenti, hypomelanosis of Ito

• Metabolic disorders

  • secondary to storage or cerebral edema

  • Tay-Sachs Disease, Mucopolysaccharidosis, MSUD,

  • leukodystrophies