Crouzon Syndrome (Craniofacial dysostosis)
also see Craniosynostosis

• Premature closure of coronal sutures (other sutures like sagittal and lambdoid might also be fused)
• "Crouzon-Coronal-Can't hear"
• Autosomal dominant w/ variable expression; 25% new mutations
• Gene locus 10q26, FGFR2 gene (same as Apert)
• Physical features
  • Frontal bossing
  • ocular proptosis due to shallow orbits (like Apert)
  • hypertelorism; severe cases might show a clover-leaf skull
  • hooked nose
  • small jaw (maxillary hypoplasia)
  • conductive hearing loss, optic atrophy
• Pertinent negatives
  • No hand involvement (vs Apert), intelligence is usually normal (50% MR in Apert)

For boards, ddx Apert Syndrome,  Pfeiffer Syndrome.

Suture review
midline forehead: metopic
midline: sagittal
anteriolateral: coronal
posterolateral: lambdoid

CHLA board review course 2005
Baraitser and Winter, 1996. Color Atlas of Congenital Malformation Syndromes