CMV
also see TORCH, CMV and ganciclovir

Congenital CMV

Etiology: Herpes virus

Incidence:

• Most common congenital infection
• 0.2-2.4% of all live births
• Risk highest with primary maternal infection with in utero transmission(40%)
• Only 5% of which have significant sequela
• 85-90% in-utero infections are asymptomatic
• Almost all perinatal infections are asymptomatic; if symptomatic, usually pneumonitis

In utero infection >> Cytomegalic inclusion disease:

• HSM, jaundice, petechia, purpura (“blueberry muffin”), microcephaly, intracranialcalcifications, IUGR
• Eyes: Chorioretinitis
• Ears: Sensorineural hearing loss (7%)

Diagnosis: PCR, urine culture

Treatment: Ganciclovir (Not recommended routinely)

Prognosis: Poor for symptomatic infants

CHLA Board Review 2005